130 Orlando workers set to lose their jobs

More than 130 workers in the Orlando area are expected to lose their jobs in the coming months after two companies announced permanent layoffs — and the total number of affected employees could grow significantly in 2027.

According to notices filed with the Florida Department of Commerce, pharmaceutical services company AssistRx and financial services company Hancock Whitney are preparing workforce reductions at their Orlando operations.

AssistRx could cut more than 200 jobs

AssistRx plans to eliminate 86 positions at its facility at 2400 Sand Lake Road, with the layoffs scheduled for November 30.

The cuts will affect a range of positions, including pharmacists, pharmacy technicians, supervisors, warehouse employees and management staff.

But the initial round may not be the end.

Company documents indicate that another 137 employees could be affected between January and May 2027, potentially bringing the total number of AssistRx positions impacted to more than 220.

The company has described the separations as permanent.

Hancock Whitney cutting 52 Orlando positions

Hancock Whitney is also preparing layoffs at its Orlando location on West Pineloch Avenue.

The financial services company expects to eliminate 52 positions during December, according to its notice to the state.

The company said the restructuring is connected to its acquisition and integration of One Florida Bank. Employees affected by the layoffs have already been notified, and the job losses are expected to be permanent.

Hundreds of jobs could ultimately be affected

For now, state records confirm 138 planned layoffs between the two Orlando employers — 86 at AssistRx and 52 at Hancock Whitney.

However, if AssistRx moves forward with the additional reductions outlined for 2027, the overall impact could rise substantially.

The announcements add another economic concern for Central Florida workers heading into the final months of 2026.