Jaguars vs. Eagles: Who will Win in London? Our Prediction

Ervin Shkulaku|DUANEWS | October 11, 2026

The Jacksonville Jaguars enter Sunday’s highly anticipated NFL matchup against the Philadelphia Eagles in London with momentum, confidence and a significant advantage on paper.

The Jaguars, who have started the season with a 3-1 record, face an Eagles team struggling with injuries and inconsistency.

The game kicks off at 9:30 a.m. Eastern at Tottenham Hotspur Stadium in London.

But the big question for Jacksonville fans is simple: Can the Jaguars secure another victory and improve to 4-1?

Our prediction is yes.

Why Jacksonville has the advantage

The Jaguars have enjoyed an impressive start to the 2026 season, winning three of their first four games.

Quarterback Trevor Lawrence has been an important part of that success, throwing eight touchdown passes through four games.

Jacksonville’s defense has also been impressive, limiting opponents’ scoring opportunities and helping the team establish itself as an early contender in the AFC South.

The Jaguars enter Sunday’s matchup with a stronger record and a healthier offensive lineup than Philadelphia.

Eagles face major injury problems

Philadelphia arrives in London without several important players.

Running back Saquon Barkley has been ruled out with a hamstring injury, while wide receivers DeVonta Smith and Marquise Brown are also unavailable.

The Eagles will additionally be without center Drew Kendall, safety Marcus Epps and outside linebacker Jonathan Greenard.

These absences could significantly affect Philadelphia’s ability to move the ball and protect quarterback Jalen Hurts.

Hurts remains a dangerous opponent, particularly because of his ability to escape pressure and create plays with his legs.

However, Jacksonville’s defense has an opportunity to take advantage of Philadelphia’s weakened offense.

Trevor Lawrence could make the difference

Lawrence will be one of the most important players to watch.

If the Jaguars establish their running game early and give Lawrence enough time to throw, Jacksonville could build a comfortable lead.

Wide receivers Brian Thomas Jr. and Parker Washington could play important roles in stretching the Eagles’ defense.

The Jaguars will also need to avoid turnovers and prevent Philadelphia from gaining momentum through big plays.

Our prediction: Jaguars 27, Eagles 17

DUANEWS predicts that Jacksonville will defeat Philadelphia 27-17.

The Jaguars have the advantage in recent form, defensive performance and overall team health.

Philadelphia still has enough talent to make the game competitive, but Jacksonville appears better positioned to control the matchup.

A victory would improve the Jaguars’ record to 4-1 and strengthen their early-season position in the AFC South.

Final prediction: Jacksonville Jaguars 27, Philadelphia Eagles 17.

This is a pregame sports prediction, not an official game result.